The cartoon revolves around the continued misadventures of Lloyd and Harry after reacquiring their dogshaped van now named "Otto". It also features a new character, Kitty, a female pet purple beaver who appears to be smarter than both men. It is the final Hanna-Barbera-produced show to premiere on ABC (as well as the final Hanna-Barbera-produced show to air on broadcast network television) and one of the last Saturday morning cartoons on the network not associated with The Walt Disney Company.
Matt Frewer provided the voice of Lloyd Christmas (Jim Carrey's character in the movie), while Bill Fagerbakke voiced the character of Harry Dunne (Jeff Daniels' character in the movie). The animated series was written by Bennett Yellin, co-writer of the original film.
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