The series was about two toads, Toro and Pancho, who live in the Mexican city of Tijuana. Throughout the cartoon they try to eat their prey, but always get outsmarted. They would sometimes themselves be targeted by a bird, Crazylegs Crane, and would in turn always outsmart him.
The series introduced two characters who later got their own series. The Blue Racer first appeared in "Snake in the Gracias" before getting his own series in 1972. Crazylegs Crane also spun off to his own series for television in 1978 on ABC. Both characters were voiced by Larry D. Mann, except in "Flight to the Finish" where Bob Holt voiced Crazylegs Crane.
Toro was voiced by actor Don Diamond and Pancho voiced by Tom Holland. Crazylegs Crane was voiced by Larry D. Mann. Directorial duties were split between Hawley Pratt, Art Davis, Grant Simmons, and Gerry Chiniquy.
When series began airing in 1976 as part of The Pink Panther Show, NBC redubbed Tijuana Toads and renamed it Texas Toads to make the series less offensive. A laugh track was added to the new soundtrack, and the toads were given the new names of Fatso and Banjo.